Respiratory depression leading to arrest, coma, and death has occurred with using codeine antitussives in younger kids, particularly from the below-1-calendar year infants whose ability to deactivate the drug just isn't entirely developed.

Respiratory melancholy and Demise have occurred in little ones who receivedcodeine next tonsillectomy and/or adenoidectomy and had evidenceof staying extremely-immediate metabolizers of codeine on account of a CYP2D6polymorphism. DESCRIPTION

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The presence of this polymorphism in CYP2D6 ends in non-functioning enzyme variant and will be related to lessened drug mtabolism or decreased therapeutic response when taken care of with codeine.

If you take codeine as well as far too much acetaminophen and acetylsalicylic acid (that are typically coupled with codeine), it may end up in liver toxicity and gastrointestinal bleeding. These critical healthcare situations can cause the following indicators:

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There won't be any recognized interactions concerning promethazine/phenylephrine/codeine and foods or non-alcoholic drinks.

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The narcotic antagonist, naloxone hydrochloride, could possibly be administered when important respiratory melancholy happens with promethazine and codeine; any depressant results of promethazine will not be reversed with naloxone. Diazepam could possibly be utilised to control convulsions. Steer clear of analeptics, which may result in convulsions. Acidosis and electrolyte losses needs to be corrected. An increase in temperature or pulmonary issues might sign the need for institution of antibiotic therapy.

Allergy symptoms to Elements. People who find themselves allergic to any of the next shouldn't consider promethazine/phenylephrine/codeine.

Cough is frequently secondary to an infection, not significant, and typically will recuperate on its own so treatment might not be vital.

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